An authoritative review published in Chemical Engineering&Technology systematically outlines the core control strategies of fermentation processes, from basic open-loop to advanced intelligent control, providing a clear technical blueprint for industrial production.

In the past year, research in the field of fermentation is no longer just about "adjusting parameters and adjusting production", but has begun to face the real pain points in industrial implementation: metabolic imbalance, product degradation, delayed detection, and extensive control

Mass and heat transfer play a crucial role in the efficiency, product quality, and process stability of reactions and fermentation.

Peptide drugs "is one of the fastest-growing and most innovative sub sectors in the field of biomedicine in recent years.

Ergothionein (EGT) is a sulfur-containing amino acid produced by fungi and some bacteria, which the human body cannot synthesize on its own and relies entirely on dietary supplementation.

Today, we take stock of 5 cutting-edge papers in the field of synthetic biology by 2025.

The Ministry of Industry and Information Technology has announced the shortlist for the "High Performance Bioreactor Innovation Task".

Fermentation of traditional Chinese medicine is not a new thing, its history can be traced back to ancient times. In the past, people often fermented traditional Chinese medicinal materials in pottery jars.

The safety and effectiveness of biological products depend on the precise implementation of downstream purification processes.

A few days ago, I had a meeting with a client who wrote the old saying again in the URS:
The internal cleaning of the fermentation tank must be 100% covered and there must be no dead corners

AI and automation are driving the upgrade of this core capability

Based on efficient and stable biocatalysts, precise control of environmental parameters, directional guidance of metabolic flow, combined with real-time monitoring and feedback, while ensuring sterility, ultimately achieving efficient and stable synthesis of the target product.

In the field of bioengineering, I often hear people say, "Our bacterial strains are particularly good, with high expression levels, but the results are not good after scaling up."

When the cell culture system in a 200L pilot tank is scaled up "proportionally" to a 2000L pilot tank, phenomena such as yield fluctuations, metabolic disorders, and cell apoptosis are often not simply due to operational errors.

Hyaluronic acid (HA), as a natural polysaccharide, is widely distributed in human skin, joint fluid, and connective tissue, and is a key component for maintaining skin moisture and elasticity.

Beneath the halo of this GLP-1 "star drug", a larger strategy is quietly advancing - Eli Lilly is positioning gene therapy as the next core of growth.

"40% of the fermentation broth was spilled" when the tank was being placed? Don't laugh, this can really happen

Recently, a colleague roasted: During an on-site inspection, the expert pointed out that the weld seam of a certain pipeline was located right below the support and hanger, and requested rectification. Many people were wondering, "How could the weld seam be in the wrong position? Isn't this too nitpicking?"

In the biopharmaceutical industry, there exists an invisible yet crucial "red line" - bacterial endotoxin.

As the core equipment in bioengineering, the manufacturing and operational details of bioreactors directly affect production efficiency and product quality.

In the wave of biomanufacturing, pilot platforms are highly anticipated - they are the "bridge" connecting laboratory research and development with industrial production, and a key link in promoting the landing of innovative achievements.

The safety and effectiveness of biological products depend on the precise implementation of downstream purification processes.

In bioreactor design, the selection of impellers is often treated as a "companion component"—simply pick any standard model that can rotate.

Building a synthetic biology process validation platform is a complex and systematic project.

Artificial intelligence+synthetic biology will be the hottest research field in the future.

After working in the fermentation workshop for over a decade, I have seen too many scenes of being flustered due to the "discoloration" of the fermentation broth.

The dietary supplement market in the United States is undergoing a transformation centered around "biological activity".

Based on efficient and stable biocatalysts, precise control of environmental parameters, directional guidance of metabolic flow, combined with real-time monitoring and feedback, while ensuring sterility, ultimately achieving efficient and stable synthesis of the target product.

In actual production, the most commonly used and reliable way to "disinfect" fermentation tanks is to use high-temperature steam, also known as "steaming tanks".

Many R&D teams have had the experience of connecting routes, optimizing parameters, and achieving good yields in the laboratory, but once it reaches the pilot scale, they become "unfamiliar with the environment"

Next generation bio manufacturing

It is a "bridge" connecting laboratory research and development with industrial production, and a key link in promoting the implementation of innovative achievements.

In the next decade, biomanufacturing will reshape the global industrial landscape and become a key pillar of national competitiveness

The biggest fear in winter is pipeline freezing

Apply this strategy to the modern Chinese biomanufacturing industry

Their gap is not a difference in quantity, but a gap in quality

The core of "big data+AI+biological response" is not about showing off skills, but about turning uncertainty into computable, controllable, and optimizable certainty

This process aims to separate and purify high-purity, pharmacopoeial compliant bioactive substances from complex fermentation broth.

What are the directions for fermentation optimization in the era of synthetic biology?

Some people started calling it a "miracle drug" and even joked that it could cure all diseases. But is reality really that beautiful?